M A Karsdal Selected Research

salmon calcitonin (Calcimar)

4/2015	Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials.
4/2015	OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.
2/2012	Oral salmon calcitonin improves fasting and postprandial glycemic control in lean healthy rats.
10/2011	A novel oral form of salmon calcitonin improves glucose homeostasis and reduces body weight in diet-induced obese rats.
4/2011	Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials.
4/2011	Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.
6/2010	Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation.
2/2010	The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study.

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M A Karsdal Research Topics

Disease

22	Osteoarthritis 01/2022 - 08/2006
21	Bone Resorption 07/2017 - 02/2000
17	Osteoporosis 01/2015 - 10/2005
16	Inflammation (Inflammations) 01/2020 - 04/2008
11	Fibrosis (Cirrhosis) 02/2021 - 07/2010
7	Disease Progression 07/2021 - 05/2011
6	Neoplasms (Cancer) 03/2019 - 01/2004
5	Knee Osteoarthritis 01/2019 - 04/2015
5	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 07/2010
4	Pain (Aches) 01/2019 - 01/2015
4	Joint Diseases (Joint Disease) 07/2017 - 10/2005
3	Weight Loss (Weight Reduction) 11/2021 - 02/2012
3	Insulin Resistance 11/2021 - 10/2011
3	Idiopathic Pulmonary Fibrosis 07/2021 - 11/2015
3	Lung Neoplasms (Lung Cancer) 01/2018 - 11/2015
3	Arthritis (Polyarthritis) 11/2017 - 07/2006
3	Breast Neoplasms (Breast Cancer) 01/2015 - 01/2004
3	Ankylosing Spondylitis 10/2013 - 05/2012
3	Neoplasm Metastasis (Metastasis) 05/2011 - 05/2003
2	Crohn Disease (Crohn's Disease) 01/2021 - 01/2017
2	Ulcerative Colitis 01/2021 - 01/2018
2	Atherosclerosis 01/2020 - 01/2011
2	Rupture 01/2020 - 03/2016
2	Lung Diseases (Lung Disease) 03/2019 - 11/2015
2	Arthralgia (Joint Pain) 01/2019 - 08/2018
2	Hemophilia A (Haemophilia) 07/2017 - 12/2016
2	Hemorrhage 12/2016 - 03/2016
2	Portal Hypertension 11/2015 - 11/2013
2	Dementia (Dementias) 01/2015 - 01/2012
2	Osteoporotic Fractures 03/2013 - 01/2007
2	Osteopetrosis 03/2012 - 10/2005
2	Body Weight (Weight, Body) 02/2012 - 10/2011
2	Obesity 02/2012 - 10/2011
2	Rheumatoid Arthritis 04/2008 - 03/2007
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 02/2021
1	COVID-19 02/2021
1	Interstitial Lung Diseases (Interstitial Lung Disease) 02/2021
1	Infections 02/2021
1	Abdominal Aortic Aneurysm 01/2021
1	Colitis 01/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021
1	Atherosclerotic Plaque (Atheroma) 01/2020
1	Hypertrophy 01/2019
1	Incisional Hernia 09/2018
1	Inguinal Hernia (Direct Inguinal Hernia) 09/2018
1	Hernia (Hernias) 09/2018
1	Sclerosing Cholangitis 01/2018

Drug/Important Bio-Agent (IBA)

45	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2003
20	CollagenIBA 07/2021 - 05/2003
13	Pharmaceutical PreparationsIBA 01/2019 - 10/2006
11	Matrix Metalloproteinases (MMPs)IBA 01/2017 - 10/2001
10	Collagen Type II (Type II Collagen)IBA 11/2017 - 07/2006
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 05/2011
8	salmon calcitonin (Calcimar)FDA LinkGeneric 04/2015 - 02/2010
7	EpitopesIBA 03/2019 - 07/2010
6	Collagen Type I (Type I Collagen)IBA 01/2016 - 05/2007
5	EnzymesIBA 01/2021 - 07/2006
5	Complement C3 (C3 Complement)IBA 01/2018 - 11/2013
5	Estrogens (Estrogen)FDA Link 01/2015 - 08/2006
5	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 04/2011 - 07/2006
4	Collagen Type V (Type V Collagen)IBA 09/2018 - 01/2012
4	Collagen Type III (Type III Collagen)IBA 08/2018 - 07/2010
3	ImmunosorbentsIBA 01/2021 - 07/2010
3	Biological ProductsIBA 01/2020 - 10/2013
3	Complement C5 (Complement 5)IBA 09/2018 - 01/2017
3	catch-relaxing peptide (Mytilus)IBA 07/2017 - 01/2014
3	C-Reactive ProteinIBA 07/2017 - 05/2012
3	Peptide Hydrolases (Proteases)FDA Link 01/2015 - 02/2000
2	Calcitonin Receptors (Calcitonin Receptor)IBA 11/2021 - 01/2019
2	Islet Amyloid PolypeptideIBA 11/2021 - 01/2019
2	fibroblast growth factor 18IBA 01/2020 - 11/2017
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2019 - 01/2017
2	tanezumabIBA 01/2019 - 01/2017
2	Peptides (Polypeptides)IBA 01/2016 - 04/2011
2	ElastinIBA 11/2015 - 11/2015
2	Diphosphonates (Bisphosphonates)IBA 10/2013 - 01/2004
2	TabletsIBA 03/2013 - 04/2011
2	Gonadal Steroid Hormones (Sex Hormones)IBA 12/2012 - 04/2011
2	Glucose (Dextrose)FDA LinkGeneric 02/2012 - 10/2011
2	strontium ranelate (protelos)IBA 04/2011 - 01/2007
2	Tartrate-Resistant Acid PhosphataseIBA 01/2011 - 08/2006
2	Ibandronic Acid (Boniva)FDA Link 10/2010 - 01/2004
1	Carbon MonoxideIBA 07/2021
1	Fibrillar CollagensIBA 07/2021
1	SandIBA 02/2021
1	SodiumIBA 01/2021
1	Dextrans (Dextran)FDA Link 01/2021
1	CalciumIBA 01/2020
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2020
1	LipidsIBA 01/2020
1	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 03/2019
1	Nerve Growth Factor (NGF)IBA 01/2019
1	Collagen Type XIBA 01/2019
1	aggrecanaseIBA 08/2018
1	Hyaluronic Acid (Hyaluronan)IBA 01/2018

Therapy/Procedure

12	Therapeutics 11/2021 - 01/2004
2	Glycemic Control 11/2021 - 02/2012
2	Injections 03/2013 - 10/2011
2	Hormone Replacement Therapy (Therapy, Hormone Replacement) 05/2007 - 08/2006
1	Herniorrhaphy 09/2018